According to one study, having a higher body mass index (BMI) is linked to a rather high blood sugar level. increased risk COVID-19 infection and prolonged COVID.
Findings by Dr Anika Knuppel from the MRC Unit for Lifelong Health and Aging, University College London, UK, and colleagues presented at this year’s European Association for the Study of Diabetes (EASD) Annual Meeting (19-23) in Stockholm, Sweden are going. September).
“Preliminary epidemiological research identified Diabetes and obesity as risk factors for becoming seriously ill from COVID-19, And we know that many people with type 2 diabetes are also carrying more weight. Our initial findings support the idea that obesity-related mechanisms may account for the additional risks of COVID-19 associated with diabetes, rather than high blood sugar.”
Previous research has shown that people with diabetes and obesity are more likely to become seriously ill and die if caught. COVID-19, but it is highly unlikely to contract. However, the underlying mechanisms and their role in prolonged COVID-19 symptoms (prolonged COVID) are unclear.
To learn more, the researchers looked for associations between a range of clinical characteristics measured before the pandemic – HbA1c (average blood sugar level), self-reported or medication-based diabetes, body mass index. (BMI) and waist-to-hip ratio (WHR)- and self-reported COVID-19 infections and long-term COVID-19 in nine ongoing UK cohort studies ,
The analysis included the most recent measurement of HbA1c (taken between 2002 and 2019), weight, height, waist and hip circumferences from each study, as well as information from questionnaires on health and lifestyle.
All eligible participants (maximum 31,252, 19-75 years of age, 57% female) had data on previous measurements and did less covering questions on COVID-19 during the COVID-19 pandemic (May 2020 to September 2021). Completed at least one questionnaire and, where possible, questions on the length of ongoing COVID-19-related symptoms.
Participants reported having COVID-19 on the basis of a positive test or strong suspicion. Long COVID was defined as symptoms that persisted or affected work for more than four weeks following infection and were compared to those reporting symptoms that lasted less than four weeks.
Where possible, associations were adjusted for sex, smoking, ethnicity, income and education at the time of measurement.
Between May 2020 and September 2021, 5,806 participants reported ever having COVID-19, and 584 reported having prolonged COVID (about 7% of COVID-19 cases with information on the length of symptoms).
An analysis of data from 31,252 participants in nine studies found that higher BMI was associated with greater odds of COVID-19 infection – with a 7% higher risk for every 5 kg/m2 increase in BMI. In overweight people (BMI 25-29.9 kg/m2) and obese (30 kg/m2 or more) compared with healthy-weight individuals (less than 25 kg/m2), respectively, COVID-19 There were 10% and 16% higher odds of infection; See figure in Note to Editors).
Similar results were observed for longer COVID (4,243 participants, six studies) – the risk is 20% higher for every 5 kg/m2 increase in BMI. Overweight and obese people were 20% and 36% more likely to have long-term COVID, respectively. However, the longer COVID associations with categories of COVID infection and BMI were not statistically significant for both (so we cannot be sure that they are not due to coincidence).
The analysis examining association with WHR was inconclusive.
Specifically, studies focusing on mean blood glucose level (HbA1c) and diabetes (15,795 participants and 1,917 for long-COVID) showed no association with either COVID-19 or long-COVID.
The researchers stress the need for more research to explore the mechanisms underlying these associations and to reduce the additional risk associated with high BMI. “Our initial findings suggest an association of adiposity with COVID-19 infection and longer COVID-19, even after taking into account socio-demographic factors and smoking. We need to further explore whether overweight and obese individuals What makes people at risk of worse outcomes and how does this relate to severe cases”, Knuppel says.
The authors acknowledge that the study was based on observation and cannot prove that higher BMI increases the risk of COVID-19 infection, and they cannot rule out the possibility that other non-measurable factors (eg, underlying conditions) or missing data may have affected the results. They also point out that COVID-19 was based on suspicion rather than a positive test, and that clinical measurements taken before the pandemic may be out of date for some of the included studies. Finally, they note that the study participants were healthier than the general population which may limit the conclusions that can be drawn.
This story has been published without modification in text from a wire agency feed.