Dementia affects approximately 55 million people worldwide, and the prevalence of the disease continues to rise. The population is expected to triple by 2050, especially in low- and middle-income countries. Dementia not only reduces quality of life of people but also places significant economic burden on families and society.
Epidemiological studies have shown an association between the temporal distribution of energy intake over the course of a day (TPEI) and its exposure to Various chronic diseases like diabetes and high blood pressure, However, evidence regarding the association between TPEI and cognitive function at the population level is relatively lacking.
Previous studies in animal models have shown that interruption of meal times Can cause changes in the clock rhythm in the hippocampus, affecting cognitive function. According to a short-term intervention trial of 96 young adults, dividing the same amount of food into four meals between 9 a.m. and 3 p.m. improved cognitive function compared to eating twice a day between 9 a.m. and 3 p.m. It is possible However, long-term studies on TPEI and cognitive function are lacking.
Recently, Drs Changzheng Yuan and Dongmei Yu at Zhejiang University published a paper in Life Metabolism titled “Temporary patterns of energy intake and cognitive function and its decline: a community-based cohort study in China” China Nutrition Health Survey. (CHNS) basis. Public database, a total of 3,342 participants were included in this study, who were middle-aged and older adults (mean age 62 years) from nine provinces of China with a baseline age of >= 55 years.
The researchers used: 1) a data-driven k-means algorithm to identify six patterns of TPEI, including the “evenly distributed” pattern, the “breakfast-dominant” pattern, the “lunch-dominant” pattern, ” The dinner-dominant” pattern, the “breakfast-rich” pattern, and the “breakfast-skipping” pattern; 2) Cognitive function was assessed using the Modified Telephone Interview for Cognitive Status (TICS-M), which included immediate and delayed word recall (20 points), backward counting (2 points), and serial-7 subtraction tests ( 5 points) were included. The overall global cognitive score ranged from 0 to 27, with a higher score representing an improved cognitive function; 3) Correlation of TPEI to cognitive function over 10 years was assessed using linear mixed models (LMMs) based on age, gender, residence, total energy, physical activity, smoking status, alcohol consumption, household income , was adjusted for education level. and body mass index (BMI).
The results showed that, compared with those with an “evenly distributed” pattern, long-term cognitive function scores were significantly lower in those who had unbalanced TPEIs, especially those with the “breakfast-skipping” pattern. Thus, maintaining a balanced TPEI has potentially positive effects on cognitive health, whereas skipping breakfast may significantly increase the risk of cognitive decline in middle-aged and older adults. In conclusion, this study highlights the importance of optimal TPEI in cognitive function.
This story has been published without modification in text from a wire agency feed.